Thanks to the relative independence that the Hegemony assured, a new period of development began in Samos. The road system was built, the sector of public health and the education were organized and there was an important development of arts and sports.

In 1849 with the publishing of the New Administrative Charta the common law was redefined to a more liberal direction. The special political system of Samos was the cause for the development of social and political institutions different from those of other islands.

In 1837 the central school of Vathi was founded, a high school in Mitilinioi and other schools in the villages and in 1854 the central school of Vathi became the 1st Pythagorio High School.

Between 1842 until 1862 the new port of Tigani (Pythagorio) was built having as foundation the ancient port of Samos. In 1863 the first newspaper �Samos� was printed. All official decrees of the Hegemony were published by �Samos�.

From 1881 until 1912 there were continuous struggles for independence form the sultan. The 11th of November 1912 in the church of Agios Spiridonas the representatives of the people of Samos unanimously voted the unification of the island with Greece. The leading figure of the unification was Themistoklis Sophoulis.